A recent article published on Science by Oliva and coworkers brilliantly describes how sex-biased gene expression extensively occurs in tissues, even in tissues that do not contribute to characteristic sexually dimorphic traits. Using Genotype-Tissue Expression (GTEx) data, the authors showed that 37% of genes in at least one of the 44 tissues studied exhibit a tissue-specific, sex-biased gene expression and described cis expression quantitative trait loci (eQTLs) with sex-differentiated effects.
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